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Covifor - Remdesivir Injection

COVIFOR is used for treatment of corona virus disease 2019 (COVID-19) in adults and children hospitalized with severe disease.

Covifor - Remdesivir Injection
Covifor - Remdesivir for Injection

Currently, there is no approved product to treat COVID-19. U.S. Food and Drug Administration (FDA) and Drug Controller General of India (DCGI) have given special approvals for use of Remdesivir for the treatment of COVID-19 under special circumstances considering the pandemic situation.

This fact sheet contains information to help you understand the risks and benefits of taking remdesivir, which you have received or may receive.

Talk to your healthcare provider if you have questions. It is your choice to receive remdesivir or stop it at any time.

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Frequently Asked Questions

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COVID-19 is caused by a virus called a coronavirus. This is a new type of coronavirus and has not been seen before. This new coronavirus was first found in people in Wuhan, Hubei Province, China in December 2019. Person-to-person spread was reported outside Hubei and in countries outside China, including in India. You can get COVID-19 through contact with another person who has the virus.

COVID-19 illnesses have ranged from very mild (including some with no reported symptoms) to severe, including illness resulting in death. The severity of this infection depends on the concomitant disease states of the person along with age. Older people and people of all ages with severe, long lasting (chronic) medical conditions like heart disease, lung disease and diabetes, for example, seem to be at higher risk of being hospitalized for COVID-19.

After exposure the symptoms may appear within 2 to 14 days which includes fever, cough, and shortness of breath. Some less common symptoms are diarrhea, skin rash and loss of taste or smell. Other medical conditions may become worse in case you have serious COVID-19 illness including breathing problems.

COVIFOR is an injection containing the drug remdesivir. Remdesivir is an investigational antiviral medicine to treat certain people in the hospital with COVID-19. Remdesivir is still being studied due to which it is called investigational. Currently, there is limited information known about the safety and effectiveness of using remdesivir to treat people in the hospital with COVID-19.

As per the clinical trials, remdesivir was shown to shorten the time to recovery in some people. There are no drugs approved for the treatment of COVID-19 by the FDA as safe and effective. Therefore, the FDA has authorized the emergency use of remdesivir for the treatment of COVID-19 under an Emergency Use Authorization (EUA). The Drug Controller General of India (DCGI) has granted an accelerated approval of this drug to meet the urgent medical need for the treatment of COVID-19 through restricted medical use.

Tell your healthcare provider about all of your medical conditions, including if you:

  • Have any allergies
  • Have kidney or liver problems
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed
  • Have any serious illnesses such as heart disease or diabetes
  • Have been taking any medications for any other illnesses
  • Are taking any medicines (prescription, over-the-counter, vitamins, or herbal products). Remdesivir may affect the way other medicines work, and other medicines may affect how remdesivir works.
  • Especially tell your healthcare provider if you are taking the medicines chloroquine phosphate or hydroxychloroquine sulfate.

COVIFOR is given to you through a vein (intravenous or IV) in a dose of 200 mg on day one followed by 100 mg from day 2 to day 5. Dosing above 5 days is not recommended. The doctor may consider the days of treatment depending on your health condition. Remdesivir may help decrease the amount of the coronavirus in your body. This may help you to get better faster.

Possible side effects of remdesivir are:

  • Allergic reactions: Remdesivir can cause allergic reactions, including serious reactions, during and after infusion. Tell your healthcare provider or nurse, or get medical help right away if you get any of the following signs and symptoms of allergic reactions.
  • Low blood pressure
  • Changes in your heartbeat
  • Shortness of breath
  • Wheezing
  • Swelling of your lips, face, or throat
  • Rash
  • Nausea
  • Vomiting
  • Sweating or Shivering
  • Increases in levels of liver enzymes: Increases in levels of liver enzymes have been seen in people who have received remdesivir, which may be a sign of inflammation or damage to cells in the liver. Your healthcare provider will do blood tests to check your liver before you receive remdesivir and daily while receiving remdesivir.

These may not be all the possible side effects of remdesivir. Since remdesivir is still being studied there is a chance that all of the risks are not yet known at this time.

Not many people have taken remdesivir as of now. Serious and unexpected side effects may happen to some people. The usual side effects of getting any medicine by vein may include brief pain, bleeding, bruising of the skin, soreness, swelling, and possible infection at the injection site.

There is limited experience giving remdesivir to pregnant women or breastfeeding mothers. For a mother and unborn baby, the benefit of receiving remdesivir may be greater than the risk from the treatment. If you are pregnant or breastfeeding, discuss your options and specific situation with your healthcare provider.

Tell your healthcare provider right away if you have any side effect that bothers you or does not go away.

You can report the side effects on Hetero helpline no. 1800-120-8689 or write us on drugsafetyindia@heterodrugs.com.

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Reference

1. COVIFOR, DCGI product permission, (accessed on: 31.07.2020)

2. COVIFOR, package insert (accessed on: 31.07.2020)

3. Fact Sheet for Patients And Parents/Caregivers Emergency Use Authorization (EUA) Of Remdesivir For Coronavirus Disease 2019 (COVID-19) (accessed on: 31.07.2020)

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Available in the Hospitals - All OVER INDIA

Remdesevir is used by doctors for the treatment of coronavirus disease 2019 (COVID-19). Currently, there is no approved product to treat COVID-19.

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Sy.No 80-84, Melange Towers, 4th Floor, C Wing, Patrika Nagar, Madhapur, Hyderabad, Telangana, 500081, India.

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